Leptin Treatment in Activity-Based Anorexia
نویسندگان
چکیده
منابع مشابه
Heat reversal of activity-based anorexia: implications for the treatment of anorexia nervosa.
OBJECTIVE Activity-based anorexia (ABA) provides an animal model of anorexia nervosa (AN). In this model, rats given restricted access to food but unrestricted access to activity wheels, run excessively while reducing food intake, lose a sizeable percentage of body weight, become hypothermic, and can fail to recover unless removed from these conditions. METHOD Once rats had lost 20% of body w...
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Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass. It decreases food intake and increases energy expenditure by affecting the balance between orexigenic and anorexigenic hypothalamic pathways. Low leptin levels are responsible for the compensatory increase in appetite and body weight and decreased energy expenditure (EE) following caloric deprivation. T...
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Anorexia nervosa (AN) tends to be a chronic and deadly disorder with no proven treatments that reverse core symptoms in adults. New insight into neurobiological mechanisms that contribute to symptoms may support development of more effective interventions. We describe the development of a temperament-based treatment for AN on the basis of empirically supported models. It uses a systemized appro...
متن کاملEvidence-based treatment of anorexia nervosa.
This paper addresses the question "Is evidence-based treatment of anorexia nervosa possible?" "Barely" is the conclusion drawn. New forms of treatment are needed for adults with anorexia nervosa, and the true value of family-based treatment for adolescents has yet to be established.
متن کاملFenfluramine treatment in female rats accelerates the weight loss associated with activity-based anorexia.
Serotonin plays an important role in controlling food intake and regulating body weight. Thus, altered serotonergic function may be involved in the etiology of anorexia nervosa. To investigate this hypothesis, we examined whether activation of the serotonin system increases the severity of activity-based anorexia, an animal model of anorexia nervosa in which food-restricted rats are housed with...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2005
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2005.03.011